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An editorial digest of the Melanotan 2 literature, read alongside its melanocortin cousins.

Amounts used in tests

Melanotan 2 in studies: amounts, shots, and time in blood

You'll see what workers gave people, mice, or rats. The numbers explain those tests. They don't tell you what to put in your body.

What these study amounts can tell you

This page lists amounts used in Melanotan 2 studies. It isn't a how-to page. Melanotan 2 isn't approved for people. No large test has found an amount that's safe for you.

The few human tests used small shots under the skin. Workers changed the amount to match each man's weight. Tests in mice and rats used other methods. Some put the compound into the brain while studying hunger. Those animal methods don't belong in personal care.

More didn't always help more. One rat test asked whether a crushed leg nerve could regain feeling. Only the middle amount helped feeling return. Both a lower and a higher amount failed. No sound human test shows how long Melanotan 2 stays in blood. Your age, your health, and your medicines can affect your risk. These lab numbers can't give you a safe amount.

What amounts the human tests used

Only small tests have given Melanotan 2 to people. The 1996 test started at 0.01 milligrams for each kilogram of body weight. It rose to 0.025–0.03 milligrams for each kilogram. Men got a shot under the skin every other weekday for two weeks. Workers picked 0.025 milligrams per kilogram each day for more early work [2].

The erection test used one under-the-skin shot. It held 0.025 milligrams per kilogram [3]. These numbers only tell you what workers did under watch. They aren't directions for your use or your body. Melanotan 2 isn't approved for people [4]. No larger test has set a safe human amount [4].

What amounts the human tests used

What Melanotan 2 shots and other test methods changed

Human tests used shots under the skin [2]. People also use these shots on their own, outside a prescriber's care. Animal tests used other methods. Some put the compound into a vein. Others put 0.1–1 nanomoles, a tiny lab measure, into the reward center on both sides of a mouse's brain [39]. Those animal methods don't give you a human use plan.

Researchers tried to help feeling return after a rat's leg nerve was crushed. A shot of 20 micrograms per kilogram, with each microgram equal to one millionth of a gram, helped feeling return when given every 48 hours. Shots of 2 and 50 micrograms per kilogram didn't help.

Your body breaks down most of the compound when swallowed. Very little gets into the blood by mouth. Illegal nose sprays appear in medical reports. No sound test shows that a nose spray gets enough drug into your blood [11]. A seller's method can't show that the compound is safe. You can't turn an animal test into your own care.

What Melanotan 2 shots and other test methods changed
Promise Peptides at mypromise.com: melanotan II product card, Rx only.
Prescription accessPromise Peptides (mypromise.com) displays its prescription-only melanotan II product here. The card's Rx-only line describes the product; it does not promise a prescription.

A route is not a recommendation

The paper records an injection; it does not issue a protocol

The injection methods in these papers are study facts, not a route to care. For prescription-only melanotan II, Promise Peptides has begun prescribing at mypromise.com after a licensed U.S. clinician's assessment of each request. The clinician may refuse a request. Only patients living in the United States can use the service, and state rules differ for each treatment. The compounded product has no FDA approval.

How long Melanotan 2 may stay in blood

People often ask about Melanotan 2 half life. Half-life means the time blood takes to lose half the drug. No sound human test has measured that time for Melanotan 2. One rat test found fast clearing from blood. A rat result can't give you a sure time for your body.

The numbers come from Melanotan I, a related drug tested in people. That study found two clearing stages after a shot under the skin. In the first stage, half left the blood in about 0.07–0.79 hours. In the slower stage, half left in about 0.8–1.7 hours. No drug was found in blood after swallowing [14].

Skin color can last for weeks after the drug leaves [14]. Color-making cells can keep making melanin after the hormone's effect ends. The paper says the ring shape slows how fast your body breaks the compound down [1]. None of these facts sets a safe way to store or use Melanotan 2 yourself.